Hydrochloric Acid → HCID 136364529、化合物

HRID 510053ノート

反応式

HRID 510053 の反応式
[Si]([O:8][C:9]1[C:10]([NH2:33])=[N:11][C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)=[N:13][C:14]=1[NH2:15])(C(C)(C)C)(C)C.Cl>O1CCCC1>[NH2:33][C:10]1[C:9]([OH:8])=[C:14]([NH2:15])[N:13]=[C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)[N:11]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66614198HCID 66614198、化合物

生成物 1

HCID 136364529HCID 136364529、化合物収率 47.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

447 mg (0.96 mmol) of the compound obtained in example 57A were initially charged in 10 ml of tetrahydrofuran, and 6 ml of 3M hydrochloric acid were added. The next day, the mixture was concentrated to dryness and the residue was stirred with acetonitrile, water and dimethylformamide The precipitate was filtered off and washed with acetonitrile. 159 mg of the title compound were obtained (92% purity; 43% of theory).

後処理

  1. concentrationThe next day, the mixture was concentrated to dryness
  2. filtrationwas filtered off
  3. washwashed with acetonitrile

出典と根拠

ORDレコード
ord-2121db27b8f94743abe1dbe622b30754
出典データセット
uspto-grants-2015_08
特許番号
US09096592B2

反応ノート

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