6-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrido[2,3-b]pyrazine → 6-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

HRID 510138

反応式

[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[CH:15]=[CH:16][C:17]3[C:18]([N:23]=2)=[N:19][CH:20]=[CH:21][N:22]=3)=[N:6]1>CO.[Pt](=O)=O>[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]2[CH:15]=[CH:16][C:17]3[NH:22][CH2:21][CH2:20][NH:19][C:18]=3[N:23]=2)=[N:6]1

参加物

実験手順

80 mg (0.22 mmol) of the compound from example 68 were initially charged in methanol (4 ml), then 12 mg (0.045 mmol) of platinum(IV) oxide were added and the reaction mixture was hydrogenated at standard pressure overnight. The reaction mixture was filtered through Celite and the filtercake was washed with methanol. The filtrate was concentrated to give 79 mg (92% purity, 90% of theory) of the title compound, which were converted without further purification.

後処理

customwas hydrogenated at standard pressure overnight
filtrationThe reaction mixture was filtered through Celite
washthe filtercake was washed with methanol
concentrationThe filtrate was concentrated

出典と根拠

ORDレコード: ord-fde0969b986f48069664c46ed83d5242
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09096592B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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