Dimethylformamide → 2-Fluoro-3-(trifluoromethyl)benzoyl chloride

HRID 510232ノート

反応式

HRID 510232 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13]C=1C(O)=O.CN(C=O)C>C(Cl)Cl>[F:7][C:8]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:1]=1[C:2]([Cl:4])=[O:3]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 5180022-Fluoro-3-(trifluoromethyl)benzoic acid

生成物 1

HCID 27375592-Fluoro-3-(trifluoromethyl)benzoyl chloride収率 99.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Oxalyl chloride (0.488 mL, 5.76 mmol) was added to a suspension of 2-fluoro-3-(trifluoromethyl)benzoic acid (1.00 g, 4.81 mmol) in DCM (10 mL) containing catalytic DMF. The reaction was stirred at room temperature for 90 minutes and solvents were removed in vacuo to afford the desired compound (1.08 g, 99%). The product was used without additional purification.

後処理

  1. customsolvents were removed in vacuo

出典と根拠

ORDレコード
ord-050408838199402b9bf1d1e4faa20359
出典データセット
uspto-grants-2015_08
特許番号
US09096596B2

反応ノート

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