Nitromethane → 4-Chloro-2-methyl-1-(2-nitrovinyl)benzene

HRID 510632ノート

反応式

HRID 510632 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([CH3:10])[CH:3]=1.Cl.CN.C([O-])(=O)C.[Na+].[N+:19]([CH3:22])([O-:21])=[O:20]>O.ClCCl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:22][N+:19]([O-:21])=[O:20])=[C:4]([CH3:10])[CH:3]=1

参加物

7

反応物 4

HCID 6375NitromethaneHCID 517045Sodium AcetateHCID 27576584-Chloro-2-methylbenzaldehydeHCID 6364545Methylamine hydrochloride

生成物 1

HCID 670259694-Chloro-2-methyl-1-(2-nitrovinyl)benzene収率 94%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 4-chloro-2-methylbenzaldehyde (1.56 g, 10.1 mmol), methylamine hydrochloride (0.44 g, 6.5 mmol), and sodium acetate (0.53 g, 6.5 mmol) in nitromethane (4 mL) was vigorously stirred at ambient temperature for 24 hours. The reaction mixture was diluted with water (20 mL) and dichloromethane (40 mL). The organic layer was dried over sodium sulfate and evaporated to afford 4-chloro-2-methyl-1-(2-nitrovinyl)benzene as a light brown solid (1.87 g, 94% yield).

後処理

  1. dry with materialThe organic layer was dried over sodium sulfate
  2. customevaporated

出典と根拠

ORDレコード
ord-ab36ae914539488985cc6db4e457eaf8
出典データセット
uspto-grants-2015_08
特許番号
US09096567B2

反応ノート

読み込み中…