2-Chloroethyl chloroformate → 3-(6-Acetyl-4-chloro-3'-fluoro-3-methylbiphenyl-2-yl)-1,3-oxazolidin-2-one

To a mixture of 1-(6-amino-4-chloro-3′-fluoro-5-methylbiphenyl-2-yl)ethanone (100 mg, 0.4 mmol) and 4-dimethylaminopyridine (53 mg, 0.43 mmol) in tetrahydrofuran (1 mL) was added 2-chloroethyl chloridocarbonate (0.041 mL, 0.40 mmol). The mixture was stirred at room temperature overnight. To the mixture was added 1.0 M potassium tert-butoxide in tetrahydrofuran (0.79 mL) at 0° C., and the resulting mixture stirred at room temperature for 2 hours, then quenched with aq. ammonium chloride, extracted with ethyl acetate. The combined organic layers were washed with brine, dried, and evaporated. The filtrate was applied on silica gel, eluting with 0 to 60% ethyl acetate in hexane, to give the desired product (14 mg, 10%). LCMS calculated for C18H16ClFNO3 (M+H)+: m/z=348.1. found: 348.0.

1. stirringthe resulting mixture stirred at room temperature for 2 hours
2. customquenched with aq. ammonium chloride
3. extractionextracted with ethyl acetate
4. washThe combined organic layers were washed with brine
5. customdried
6. customevaporated
7. washeluting with 0 to 60% ethyl acetate in hexane

ORDレコード

ord-91bd185a75854b099fb88102c3c795a6

出典データセット

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09096600B2