1-(5-Chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanone → HCID 86666790、化合物

HRID 510859ノート

反応式

HRID 510859 の反応式
[Cl:1][C:2]1[C:3]([CH3:16])=[C:4]([N+:13]([O-])=O)[C:5]([O:11][CH3:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.[H][H]>CO.[Pt]>[NH2:13][C:4]1[C:5]([O:11][CH3:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=[C:2]([Cl:1])[C:3]=1[CH3:16]

参加物

5

反応物 2

HCID 27576391-(5-Chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 86666790HCID 86666790、化合物

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

1-(5-Chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanone (5.0 g, 20 mmol) was hydrogenated in 100 mL of methanol in the presence of 0.5 g of 10% Pt/C, under a balloon pressure of hydrogen overnight. The catalyst was filtered off and the filtrate was concentrated. The residue was dissolved in dichloromethane and dried over sodium sulfate and then evaporated to dryness. The crude product was used directly in next step (4.4 g, 100%). LCMS calculated for C10H13ClNO2 (M+H)+: m/z=214.1. found: 214.1.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated
  3. dissolutionThe residue was dissolved in dichloromethane
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-7faae9379b584c049d8a8ac3a14c5080
出典データセット
uspto-grants-2015_08
特許番号
US09096600B2

反応ノート

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