Diethyl(4-nitrophenyl)phosphonate → Diethyl (4-aminophenyl)phosphonate

HRID 511218

反応式

HRID 511218 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].CCO>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([P:10](=[O:17])([O:11][CH2:12][CH3:13])[O:14][CH2:15][CH3:16])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 284865Diethyl(4-nitrophenyl)phosphonateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 273213Diethyl (4-aminophenyl)phosphonate収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of diethyl (4-nitrophenyl)phosphonate (150 mg, 0.58 mmol), EtOH (40 ml) and 10% Pd/C (30 mg) was hydrogenated under 50 psi of hydrogen pressure at 40° C. for 6 h. After cooling to room temperature, the reaction mixture was filtered and the filtrate concentrated in vacuo to afford 130 mg of desired diethyl (4-aminophenyl)phosphonate (yield: 98%), which was used directly in further chemistries without purification.

後処理

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-f842427ccf7c41a7a71ee9cfbcc452a0
出典データセット
uspto-grants-2015_08
特許番号
US09096624B2

関連ノート

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