Trifluoroacetic acid → 7-amino-2-methyl-4-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-1-one

HRID 511311ノート

反応式

HRID 511311 の反応式
[CH3:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[C:5]([C:20]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:21])[CH:6]=[CH:7][C:8]=2[NH:12]C(=O)OC(C)(C)C)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:12][C:8]1[CH:7]=[CH:6][C:5]([C:20]([N:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)=[O:21])=[C:4]2[C:9]=1[C:10](=[O:11])[N:2]([CH3:1])[CH2:3]2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86654017tert-butyl[2-methyl-3-oxo-7-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-4-yl]carbamate2 回

生成物 1

HCID 672554307-amino-2-methyl-4-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-1-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To tert-butyl [2-methyl-3-oxo-7-(pyrrolidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-4-yl]carbamate (Compound 116B) was added DCM (0.5 mL) and TFA (0.5 mL). The reaction mixture was stirred at room temperature for 30 minutes, after which it was concentrated to dryness an used without further purification. MS (ES+): m/z 260.30 (100) [MH+]; HPLC: tR=0.69 min (UPLC, Analytical).

後処理

  1. concentrationafter which it was concentrated to dryness
  2. customan used without further purification

出典と根拠

ORDレコード
ord-eac491fedda84dbc88a32c530f8828b7
出典データセット
uspto-grants-2015_08
特許番号
US09096624B2

反応ノート

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