Trifluoroacetic acid → 7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

HRID 511321ノート

反応式

HRID 511321 の反応式
C(OC([NH:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 672564057-[(Tert-butoxycarbonyl)amino]-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

生成物 1

HCID 672542797-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

実験手順

The title compound was prepared by deprotecting Compound 116C with TFA. The crude product was taken on to the next step without purification.

後処理

  1. customThe crude product was taken on to the next step without purification

出典と根拠

ORDレコード
ord-90ff44e86d8349c4b9abbd8ada76d88d
出典データセット
uspto-grants-2015_08
特許番号
US09096624B2

反応ノート

読み込み中…