4-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one → 7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one

HRID 511439ノート

反応式

HRID 511439 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:4]=1[CH2:5][N:6]([CH3:16])[C:7]2=[O:15]>CO.CCOC(C)=O.[Pd]>[NH2:12][C:9]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4]2[C:8]=1[C:7](=[O:15])[N:6]([CH3:16])[CH2:5]2

参加物

5

反応物 1

HCID 598491794-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one

生成物 1

HCID 672539417-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Pd/C (7.67 mg, 0.0720 mmol) was added to a solution of 4-methoxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one in MeOH (2 mL) and EtOAc (2 mL) and the mixture was hydrogenated at stp overnight. The solution was filtered and the title compound was not further purified. MS (ES+): m/z 193.14 (100) [MH+]; HPLC: tR=0.65 min (UPLC, analytical).

後処理

  1. filtrationThe solution was filtered

出典と根拠

ORDレコード
ord-f7117982141144bc9151866a48213d0d
出典データセット
uspto-grants-2015_08
特許番号
US09096624B2

反応ノート

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