Sodium Azide → 4-Bromobenzyl azide
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:10]=[N+:11]=[N-:12])=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of 4-bromobenzyl bromide (54) and sodium azide (2.0 equiv.) in DMF was stirred at 50° C. for 3 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The combined organic extract was dried over MgSO4 and concentrated in vacuo. The residue was purified by flash chromatography to yield 55 as colorless oil in 92% yield.
後処理
- extractionextracted with CH2Cl2
- extractionThe combined organic extract
- dry with materialwas dried over MgSO4
- concentrationconcentrated in vacuo
- customThe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-be285720f74844ac9e2e1175a5d03926
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102622B2
反応ノート
読み込み中…