2-Amino-4-chlorophenol → HCID 178527795、化合物

HRID 512442ノート

反応式

HRID 512442 の反応式
O(CC)[C:2]([S-])=[S:3].[K+].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([NH2:16])[CH:10]=1>C(O)C>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]2[O:15][C:2]([SH:3])=[N:16][C:11]=2[CH:10]=1

参加物

4

反応物 2

HCID 72652-Amino-4-chlorophenolHCID 2735045Potassium ethylxanthate

生成物 1

HCID 178527795HCID 178527795、化合物収率 99.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of potassium ethyl xanthate (13.4 g, 84.0 mmol) and 4-chloro-2-aminophenol (10 g, 69.6 mmol) was dissolved in absolute ethanol (200 mL). The mixture was stirred under reflux overnight. After cooling, the solvent was evaporated under reduced pressure, the residue was dissolved in water (200 mL) and treated with HOAc to adjust pH to 5. A solid formed, which was filtered and dried to afford 5-chloro-2-mercaptobenzoxazole (12.8 g, yield 99.1%).

後処理

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in water (200 mL)
  5. additiontreated with HOAc
  6. customA solid formed
  7. filtrationwhich was filtered
  8. customdried

出典と根拠

ORDレコード
ord-333a50b1313d4f728f291bcb92d393b9
出典データセット
uspto-grants-2015_08
特許番号
US09102636B2

反応ノート

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