Water → HCID 69137025、化合物
反応式
[Br:1]N1C(=O)CCC1=O.[O:9]=[C:10]1[C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[NH:11]1.O>C(O)(=O)C>[Br:1][C:13]1[CH:14]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[C:10](=[O:9])[NH:11][C:12]=1[C:20]([F:21])([F:23])[F:22]参加物
5
実験手順
At room temperature, 0.36 g (2.04 mmol) of N-bromosuccinimide was added to a suspension of 0.3 g (1.36 mmol) of methyl 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylate in 10 ml of glacial acetic acid, and the mixture was then heated under reflux for 2 days. The reaction mixture was then added to water and extracted with dichloromethane. The extract was concentrated, and the residue was purified further by preparative HPLC. This gave 227 mg (56% of theory) of a colorless powder.
後処理
- temperaturethe mixture was then heated
- temperatureunder reflux for 2 days
- extractionextracted with dichloromethane
- concentrationThe extract was concentrated
- customthe residue was purified further by preparative HPLC
出典と根拠
- ORDレコード
- ord-26fc9d545ea24eeb9ac5de8240115e04
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102623B2
反応ノート
読み込み中…