Water → 1-Butoxy-4,4,5,5-tetrafluoropent-1-en-3-one

HRID 512467ノート

反応式

HRID 512467 の反応式
[CH:1]([F:9])([F:8])[C:2]([F:7])([F:6])[C:3](Cl)=[O:4].N1C=CC=CC=1.[CH:16]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH2:17].O>ClCCl>[CH2:19]([O:18][CH:16]=[CH:17][C:3](=[O:4])[C:2]([F:7])([F:6])[CH:1]([F:9])[F:8])[CH2:20][CH2:21][CH3:22]

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 8108Butyl vinyl etherHCID 27767442,2,3,3-Tetrafluoropropanoyl chloride

生成物 1

HCID 911638691-Butoxy-4,4,5,5-tetrafluoropent-1-en-3-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

With stirring and at 0° C., 25.0 g (152 mmol) of 3H-tetrafluoropropionyl chloride—dissolved in 20 ml dichloromethane—were added to a mixture of 14.4 g (182 mmol) of pyridine and 15.2 g (152 mmol) of butyl vinyl ether in 250 ml of dichloromethane. After the addition, stirring was continued at room temperature for another 15 h. 250 ml of water were then added to the mixture, and the organic phase was separated off, dried and concentrated. This gave 12.5 g (36% of theory) of a yellowish oil.

後処理

  1. additionAfter the addition
  2. stirringstirring
  3. customthe organic phase was separated off
  4. customdried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5e56fafd7a5f45a6890f10a5dfa365be
出典データセット
uspto-grants-2015_08
特許番号
US09102623B2

反応ノート

読み込み中…