Malonamide → 6-(2-Chloro-1,1,2,2-tetrafluoroethyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
反応式
[Na].C(O[CH:7]=[CH:8][C:9](=O)[C:10]([F:16])([F:15])[C:11]([Cl:14])([F:13])[F:12])CCC.[C:18]([NH2:24])(=[O:23])[CH2:19][C:20]([NH2:22])=[O:21]>CO>[Cl:14][C:11]([F:12])([F:13])[C:10]([C:9]1[NH:22][C:20](=[O:21])[C:19]([C:18]([NH2:24])=[O:23])=[CH:7][CH:8]=1)([F:15])[F:16]参加物
5
実験手順
0.53 g (22.8 mmol) of sodium were dissolved in 50 ml of methanol, 5.0 g (19.0 mmol) of 1-butoxy-5-chloro-4,4,5,5-tetrafluoropent-1-en-3-one and 2.0 g (19.0 mmol) of malonamide were then added and the mixture was heated under reflux for 6 h. The mixture was concentrated, and 1N hydrochloric acid was then added. The resulting precipitate was filtered off with suction and dried. This gave 3.8 g (73% of theory) of a brownish powder.
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 6 h
- concentrationThe mixture was concentrated
- addition1N hydrochloric acid was then added
- filtrationThe resulting precipitate was filtered off with suction
- customdried
出典と根拠
- ORDレコード
- ord-0547b4307ad5449ea9163b507460a573
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102623B2
反応ノート
読み込み中…