Pyridine → 1-Butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one

HRID 512480ノート

反応式

HRID 512480 の反応式
[Cl:1][C:2]([F:10])([C:6]([F:9])([F:8])[F:7])[C:3](Cl)=[O:4].N1C=CC=CC=1.[CH:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH2:18]>ClCCl>[CH2:20]([O:19][CH:17]=[CH:18][C:3](=[O:4])[C:2]([Cl:1])([F:10])[C:6]([F:9])([F:8])[F:7])[CH2:21][CH2:22][CH3:23]

参加物

5

反応物 3

HCID 1049PyridineHCID 8108Butyl vinyl etherHCID 27824982-Chloro-2,3,3,3-tetrafluoropropanoyl chloride

生成物 1

HCID 866240961-Butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

With stirring and at 0° C., 9.59 g (48.2 mmol) of 2-chlorotetrafluoropropionyl chloride were added dropwise to a mixture of 4.19 g (50.0 mmol) of pyridine and 4.83 g (48.2 mmol) of butyl vinyl ether in 75 ml of dichloromethane. After the addition, stirring was continued at room temperature for another 15 h. The mixture was then washed with 1N hydrochloric acid and 2×100 ml of water, and the organic phase was separated off, dried and concentrated. This gave 6.33 g (50% of theory) of a brown oil.

後処理

  1. additionAfter the addition
  2. stirringstirring
  3. washThe mixture was then washed with 1N hydrochloric acid and 2×100 ml of water
  4. customthe organic phase was separated off
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-4ad6f0766f9e4ce5bc41e5dca8b88e96
出典データセット
uspto-grants-2015_08
特許番号
US09102623B2

反応ノート

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