Malonamide → 6-(1-Chloro-1,2,2,2-tetrafluoroethyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
反応式
[Na].C(O[CH:7]=[CH:8][C:9](=O)[C:10]([Cl:16])([F:15])[C:11]([F:14])([F:13])[F:12])CCC.[C:18]([NH2:24])(=[O:23])[CH2:19][C:20]([NH2:22])=[O:21]>CO>[Cl:16][C:10]([C:9]1[NH:22][C:20](=[O:21])[C:19]([C:18]([NH2:24])=[O:23])=[CH:7][CH:8]=1)([F:15])[C:11]([F:12])([F:13])[F:14]参加物
5
実験手順
0.33 g (14.4 mmol) of sodium were dissolved in 50 ml of methanol, 3.16 g (12.03 mmol) of 1-butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one and 1.27 g (12.03 mmol) of malonamide were added and the mixture was heated under reflux for 7 h. The mixture was concentrated, and 1N hydrochloric acid was then added. The resulting precipitate was filtered off with suction and dried. This gave 380 mg (12% of theory) of a yellowish powder.
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 7 h
- concentrationThe mixture was concentrated
- addition1N hydrochloric acid was then added
- filtrationThe resulting precipitate was filtered off with suction
- customdried
出典と根拠
- ORDレコード
- ord-0fdb4360d4fe4d69a30d537b9be032cc
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102623B2
反応ノート
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