4-Methyl-3-nitrobenzoyl chloride → 5-(4-Methyl-3-nitrobenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide

HRID 512529

反応式

HRID 512529 の反応式
[NH2:1][C:2]1[S:6][C:5]([NH:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=2)=[N:4][C:3]=1[C:18]([NH2:20])=[O:19].[CH3:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][C:23]=1[N+:31]([O-:33])=[O:32]>N1C=CC=CC=1>[CH3:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:1][C:2]2[S:6][C:5]([NH:7][C:8]3[CH:17]=[CH:16][C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[CH:9]=3)=[N:4][C:3]=2[C:18]([NH2:20])=[O:19])=[O:27])=[CH:24][C:23]=1[N+:31]([O-:33])=[O:32]

参加物

4

反応物 2

HCID 663234-Methyl-3-nitrobenzoyl chlorideHCID 867033695-Amino-2-(naphthalen-2-ylamino)thiazole-4-carboxamide

生成物 1

HCID 867033715-(4-Methyl-3-nitrobenzamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide収率 66%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

実験手順

To a mixture of 5-amino-2-(naphthalen-2-ylamino)thiazole-4-carboxamide (0.2 g, 0.70 mmol) in pyridine (5 mL) was added a solution of 4-methyl-3-nitrobenzoyl chloride in pyridine (3 mL) at 0° C. under nitrogen atmosphere. The mixture was allowed to warm up to rt, and stirred for 16 hrs at rt. The solvent was evaporated, and the crude residue was suspended into EtOAc (20 mL). The resulting solids were collected by filtration and washed with MeOH (2×5 mL) to give 0.21 g (66% yield) of the titled compound.

後処理

  1. customThe solvent was evaporated
  2. filtrationThe resulting solids were collected by filtration
  3. washwashed with MeOH (2×5 mL)

出典と根拠

ORDレコード
ord-85ebdae6dd3244adadaa17d15c588fcb
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

関連ノート

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