2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide

HRID 512539

反応式

HRID 512539 の反応式
[N:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[CH:5]=[C:6]3[C:11](=[CH:12][CH:13]=2)[N:10]=[CH:9][CH:8]=[CH:7]3)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]

参加物

4

反応物 2

HCID 983412-Amino-2-cyanoacetamideHCID 137184226-Isothiocyanatoquinoline

生成物 1

HCID 867033765-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide収率 65.4%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.

後処理

  1. temperaturewas refluxed for 90 min
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe residue was purified by silica gel column chromatography
  4. washeluted with 2% MeOH in DCM

出典と根拠

ORDレコード
ord-c7a2e6ea4fa742208557da471a08eaa9
出典データセット
uspto-grants-2015_08
特許番号
US09102637B2

関連ノート

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