1-(4-Bromo-3,5-dimethoxyphenyl)propan-1-ol → 1-(4-Bromo-3,5-dimethoxyphenyl)propan-1-one

HRID 512684ノート

反応式

HRID 512684 の反応式
[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([CH:10]([OH:13])[CH2:11][CH3:12])=[CH:4][C:3]=1[O:14][CH3:15]>C(Cl)Cl.O=[Mn]=O>[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10](=[O:13])[CH2:11][CH3:12])=[CH:4][C:3]=1[O:14][CH3:15]

参加物

4

反応物 1

HCID 584320031-(4-Bromo-3,5-dimethoxyphenyl)propan-1-ol

生成物 1

HCID 584320651-(4-Bromo-3,5-dimethoxyphenyl)propan-1-one収率 100.9%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(4-bromo-3,5-dimethoxyphenyl)propan-1-ol (5.4 g, 19.6 mmol) in anhydrous CH2Cl2 (75 mL) was added MnO2 (17 g, 196 mmol). After the mixture was placed under a drying tube and stirred at room temperature for 22 hrs, it was filtered through a pad of Celite and silica gel and rinsed with EtOAc. Concentration of the filtrate in vacuo gave 1-(4-bromo-3,5-dimethoxyphenyl)propan-1-one as a white solid (5.4 g, 100% yield). The product was used without further purification.

後処理

  1. customAfter the mixture was placed under a drying tube
  2. filtrationit was filtered through a pad of Celite and silica gel
  3. washrinsed with EtOAc

出典と根拠

ORDレコード
ord-d22a196989ae4782a091227cd9b39ce6
出典データセット
uspto-grants-2015_08
特許番号
US09102643B2

反応ノート

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