Benzyl Chloride → Methyl 2-(benzyloxy)propanoate

HRID 512808

反応式

HRID 512808 の反応式
CC(C)([O-])C.[K+].[C:7]([O:12][CH3:13])(=[O:11])[CH:8]([CH3:10])[OH:9].[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CN(C=O)C>[CH2:14]([O:9][CH:8]([CH3:10])[C:7]([O:12][CH3:13])=[O:11])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 11040Methyl LactateHCID 23665647Potassium tert-butoxide

生成物 1

HCID 561764Methyl 2-(benzyloxy)propanoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a pre-cooled solution of potassium tertiary butoxide (538.4 g) in DMF (1750 ml) at −20 to −10° C., added racemic methyl lactate compound of formula-11 (500 g) followed by benzyl chloride (547 g) at −20 to −10° C. and the reaction mixture was stirred for 5 hours at the same temperature. After completion of the reaction, the reaction mixture was quenched with water and the reaction mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and 10% sodium chloride solution and then distilled off the solvent from ethyl acetate layer under reduced pressure to get the title compound as a residue. The obtained residue was taken into next step without isolation.

後処理

  1. customAfter completion of the reaction
  2. customthe reaction mixture was quenched with water
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. washThe ethyl acetate layer was washed with water and 10% sodium chloride solution
  5. distillationdistilled off the solvent from ethyl acetate layer under reduced pressure

出典と根拠

ORDレコード
ord-36e5364bb8604b519f3405652f340859
出典データセット
uspto-grants-2015_08
特許番号
US09102664B2

関連ノート

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