Benzyl Chloride → Methyl 2-(benzyloxy)propanoate

HRID 512810

反応式

HRID 512810 の反応式
[C:1]([O:6][CH3:7])(=[O:5])[CH:2]([CH3:4])[OH:3].[CH2:8](Cl)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)([O-])C.[Na+]>CN(C)C=O>[CH2:8]([O:3][CH:2]([CH3:4])[C:1]([O:6][CH3:7])=[O:5])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 11040Methyl LactateHCID 23676156Sodium t-butoxide

生成物 1

HCID 561764Methyl 2-(benzyloxy)propanoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
30 °C

実験手順

To a pre-cooled solution of racemic methyl lactate (200 g) in dimethyl formamide (400 ml) at 0-10° C., added benzyl chloride (218.8 g). Sodium tertiary butoxide (224.6 g) was added to the reaction mixture at 0-10° C. and stirred for 6 hours at 25-35° C. After completion of the reaction, the reaction mixture was quenched with water and extracted with toluene. The toluene layer was washed with water followed by 10% sodium chloride solution. The obtained toluene layer containing title compound was taken to next step.

後処理

  1. customAfter completion of the reaction
  2. customthe reaction mixture was quenched with water
  3. extractionextracted with toluene
  4. washThe toluene layer was washed with water
  5. additionThe obtained toluene layer containing title compound

出典と根拠

ORDレコード
ord-a26405a450844edfbca5095bd1d67402
出典データセット
uspto-grants-2015_08
特許番号
US09102664B2

関連ノート

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