Water → 8-(6-Chloropyridazin-3-yl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 512828ノート

反応式

HRID 512828 の反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[O:9]1[C:13]2([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[O:12][CH2:11][CH2:10]1.CCN(C(C)C)C(C)C.O>CS(C)=O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:16]2[CH2:17][CH2:18][C:13]3([O:12][CH2:11][CH2:10][O:9]3)[CH2:14][CH2:15]2)=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 673313,6-DichloropyridazineHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 81531Diisopropylethylamine

生成物 1

HCID 32267178-(6-Chloropyridazin-3-yl)-1,4-dioxa-8-azaspiro[4.5]decane

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
80 °C

実験手順

To a mixture of 3,6-dichloropyridazine (2.98 g, 20 mmol) in DMSO (10 mL) was added 1,4-dioxa-8-azaspiro[4.5]decane (3 g, 21 mmol) and DIPEA (4.18 mL, 24 mmol). The resulting mixture was heated at 80° C. for 4 h and was then poured into H2O (300 mL). The resulting solid was washed with H2O (10 mL×3) and hexane (10 mL×3) and then dried to yield 8-(6-chloropyridazin-3-yl)-1,4-dioxa-8-azaspiro[4.5]decane.

後処理

  1. washThe resulting solid was washed with H2O (10 mL×3) and hexane (10 mL×3)
  2. customdried

出典と根拠

ORDレコード
ord-48dd55e183604a29bef038d5fe96d56f
出典データセット
uspto-grants-2015_08
特許番号
US09102669B2

反応ノート

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