Benzyl Isothiocyanate → (cyclohexylphenylamino)-N-benzylthiocarboxamide

HRID 51291

反応式

HRID 51291 の反応式
[CH:1]1([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:14]([N:21]=[C:22]=[S:23])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(#N)C.CN(C)C1C=CN=CC=1>[CH:8]1([N:7]([C:22]([NH:21][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[S:23])[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

5

反応物 2

HCID 2346Benzyl IsothiocyanateHCID 74567N-Cyclohexylaniline

生成物 1

HCID 21304109(cyclohexylphenylamino)-N-benzylthiocarboxamide

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6342Acetonitrile溶媒

実験手順

To a solution of N-cyclohexylaniline (0.1 ml, 0.57 mmol) in acetonitrile (4 ml) was added a catalytic amount of 4-(dimethylamino)pyridine (5 mg, 0.04 mmol). To this mixture was added benzyl isothiocyanate (0.11 ml, 0.83 mmol) dropwise, and the mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on preparative silica gel plates, developing with 20% ethyl acetate/hexanes, to furnish (cyclohexylphenylamino)-N-benzylthiocarboxamide as a white solid, (M+1)=324.8.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified on preparative silica gel plates

出典と根拠

ORDレコード
ord-b72946b816d94e4e912db09fc4cec590
出典データセット
uspto-grants-2004_03
特許番号
US06713650B2

関連ノート

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