Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride
反応式
[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:23])=[O:5]参加物
5
実験手順
To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.
後処理
- custom(vigorous bubbling) for 4 h
- concentrationconcentrated to an oily solid which
- customafter overnight
- customdrying on high vacuum
出典と根拠
- ORDレコード
- ord-7e8ac219a9984f6494b1041233e4e050
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102686B2
反応ノート
読み込み中…