Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride

HRID 513218

反応式

HRID 513218 の反応式
[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:23])=[O:5]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27366772-Chloro-3-(trifluoromethyl)benzoic acid

生成物 1

HCID 38276332-Chloro-3-(trifluoromethyl)benzoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.

後処理

  1. custom(vigorous bubbling) for 4 h
  2. concentrationconcentrated to an oily solid which
  3. customafter overnight
  4. customdrying on high vacuum

出典と根拠

ORDレコード
ord-7e8ac219a9984f6494b1041233e4e050
出典データセット
uspto-grants-2015_08
特許番号
US09102686B2

関連ノート

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