Ethanol → HCID 91882220、化合物
反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([I:11])[CH:3]=1.[CH2:12](O)[CH3:13]>S(Cl)(Cl)=O>[CH2:12]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=1[I:11])[CH3:13]参加物
4
反応条件
- 温度
- 0 °C
実験手順
4-Bromo-2-iodo-benzoic acid (4.0 g; 12.24 mmol) is stirred in thionyl chloride (8.0 ml) under reflux for 1 hour. The reaction mixture is evaporated under reduced pressure and taken up immediately in 20 ml methylene dichloride and cooled down to 0° C. Ethanol (20.0 ml; 342.96 mmol) is added and stirred for 1 hour at ambient temperature. The ethanol is evaporated and the residue taken up in methylene dichloride and extracted with saturated NaHCO3 solution. The organic layer is separated, dried over MgSO4 and evaporated to dryness.
後処理
- temperatureunder reflux for 1 hour
- customThe reaction mixture is evaporated under reduced pressure
- customThe ethanol is evaporated
- extractionextracted with saturated NaHCO3 solution
- customThe organic layer is separated
- dry with materialdried over MgSO4
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-17cdf5ccef394070bdbbe23256e05bb4
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102684B2
反応ノート
読み込み中…