Hydrochloric Acid → 5-Chloro-4-fluoro-2-nitrobenzene-1-sulfonyl chloride
反応式
[O:1]=[S:2]([Cl:4])Cl.[Cl:5][C:6]1[C:7]([F:16])=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[C:10]([CH:12]=1)N.N([O-])=[O:18].[Na+].Cl>O.Cl[Cu]>[Cl:5][C:6]1[C:7]([F:16])=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[C:10]([S:2]([Cl:4])(=[O:1])=[O:18])[CH:12]=1参加物
7
実験手順
In a similar fashion using route 3a general procedure 10, SOCl2 (2.8 ml, 28.8 mmol) in water (15 ml), CuCl (26 mg, 0.26 mmol), 5-chloro-4-fluoro-2-nitroaniline (1 g, 5.2 mmol), NaNO2 (522 mg, 7.5 mmol) and conc. HCl (10 ml) gave the title compound (1.5 g) which was used in the next step without further purification. The structure was confirmed by 1H NMR.
出典と根拠
- ORDレコード
- ord-6683550bfa624031943e17fa5b3a0d0e
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102688B2
反応ノート
読み込み中…