Hydrochloric Acid → 2-Nitro-4-trifluoromethoxy-benzenesulfonyl chloride

HRID 513373ノート

反応式

HRID 513373 の反応式
[O:1]=[S:2]([Cl:4])Cl.[N+:5]([C:8]1[CH:14]=[C:13]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:11][C:9]=1N)([O-:7])=[O:6].Cl.N([O-])=[O:22].[Na+]>O.Cl[Cu]>[N+:5]([C:8]1[CH:14]=[C:13]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:11][C:9]=1[S:2]([Cl:4])(=[O:1])=[O:22])([O-:7])=[O:6]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 27757722-Nitro-4-(trifluoromethoxy)anilineHCID 23668193Sodium Nitrite

生成物 1

HCID 866697542-Nitro-4-trifluoromethoxy-benzenesulfonyl chloride収率 105.4%

試薬・触媒・溶媒 2

HCID 62652Cuprous chloride触媒HCID 962Water溶媒2 回

実験手順

In a similar fashion using route 3a general procedure 10, SOCl2 (0.36 ml, 4.95 mmol) in cold water (2 ml), CuCl (5 mg, 0.05 mmol), 2-nitro-4-(trifluoromethoxy)aniline (200 mg, 0.90 mmol), conc. HCl (2 ml), NaNO2 (90 mg, 1.3 mmol) in water (2 ml) gave the title compound (290 mg) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

出典と根拠

ORDレコード
ord-1e0fd975f5f94606babf2e5cfa5654ae
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

反応ノート

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