2-Methyl-8-nitroquinoline → 2-Methyl-8-aminoquinoline

HRID 513375

反応式

HRID 513375 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([N+:12]([O-])=O)[CH:6]=[CH:7][CH:8]=2)[N:3]=1>[Pd].CCO.CO>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([NH2:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

5

反応物 1

HCID 134332-Methyl-8-nitroquinoline

生成物 1

HCID 1404572-Methyl-8-aminoquinoline収率 99.1%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

Palladium on carbon (10%, 50 mg) was added to a solution of 2-methyl-8-nitroquinoline (500 mg, 2.66 mmol) in EtOH (40 ml) and the mixture was stirred under an atmosphere of hydrogen for 2 h. The mixture was diluted with MeOH (40 ml), filtered through celite and the filtrate was concentrated in vacuo to give the title compound (417 mg, 99%).

後処理

  1. filtrationfiltered through celite
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-f45c7a9960aa43a4b59b1fb9b3311a85
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

関連ノート

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