Ammonia → 3-Methyl-8-quinolinamine

HRID 513384

反応式

HRID 513384 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2O.S([O-])([O-])=O.[NH4+:17].[NH4+].N>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH2:17]

参加物

5

反応物 3

HCID 222AmmoniaHCID 25041Ammonium SulfiteHCID 43322813-Methylquinolin-8-ol2 回

生成物 1

HCID 157837943-Methyl-8-quinolinamine収率 91.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3-methylquinolin-8-ol (Intermediate 30) (150 mg, 0.9 mmol) and ammonium sulphite (250 mg, 1.8 mmol) were added to aqueous ammonia (3 ml) and heated for 48 h. After cooling, water was added and the mixture was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (130 mg, 86%).

後処理

  1. temperatureheated for 48 h
  2. temperatureAfter cooling
  3. extractionthe mixture was extracted with DCM
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-deb45c358e1b499eb3e02cc0c03b2144
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

関連ノート

読み込み中…