化工社化工社 化学情報印刷レポート · 研究参考用
8-Aminoquinoline → 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Aminoquinoline | HCID 11359 | — |
| 反応物 | Benzoic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 113339 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 生成物 | 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester | HCID 31702993 | 64% |
反応手順
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), methyl 3-chlorosulfonylbenzoate (160 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 64%) after purification by column chromatography with DCM as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-8dee330c2dd447c49a029927665986ad |
| 出典メモ | uspto-grants-2015_08 |