化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → 5-Methyl-pyridine-2-sulfonic acid quinolin-8-ylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 5-Methylpyridine-2-sulfonyl chloride | HCID 12295463 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-Methyl-pyridine-2-sulfonic acid quinolin-8-ylamide | HCID 68183382 | 25% |
反応手順
In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (40 mg, 0.27 mmol), 5-methyl-pyridine-2-sulfonyl chloride 440 (79 mg, 0.41 mmol), pyridine (1.5 ml) DMAP (cat.) and DCM (2 ml) gave the title compound (21 mg, 25%) after purification by column chromatography with n-hexane/EtOAc (93:7) as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-311fe6dc3e554d51b0a165ecd488016c |
| 出典メモ | uspto-grants-2015_08 |