Trifluoromethanesulfonate → HCID 60164095、化合物

HRID 513647ノート

反応式

HRID 513647 の反応式
[C:1]1([NH:7][CH2:8][C:9]2[C:18]([NH2:19])=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1([S:25](N2C=C[N+](C)=C2)(=[O:27])=[O:26])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[C:1]1([N:7]2[S:25](=[O:27])(=[O:26])[NH:19][C:18]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][N:16]=4)[CH:11]=[CH:10][C:9]=3[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150、化合物HCID 681831547-Phenylaminomethyl-quinolin-8-ylamine2 回

生成物 1

HCID 60164095HCID 60164095、化合物収率 4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 7-phenylaminomethyl-quinolin-8-ylamine (Intermediate 206) (350 mg, 1.4 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (762 mg, 2.1 mmol) in MeCN (10 ml) was stirred at 0° C. then allowed to warm to room temperature overnight. The reaction mixture was concentrated in vacuo and the crude residue was purified by preparative HPLC (basic conditions) to give the title compound (18 mg, 4%).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude residue was purified by preparative HPLC (basic conditions)

出典と根拠

ORDレコード
ord-e3896450a3ab4be08919dc43894bb617
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

反応ノート

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