Trifluoromethanesulfonate → HCID 60164096、化合物

HRID 513652ノート

反応式

HRID 513652 の反応式
[NH2:1][CH2:2][C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.N1([S:19](N2C=C[N+](C)=C2)(=[O:21])=[O:20])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[CH2:2]1[C:3]2[CH:4]=[CH:5][C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[C:12]=2[NH:13][S:19](=[O:21])(=[O:20])[NH:1]1

参加物

5

反応物 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150、化合物HCID 68183296HCID 68183296、化合物2 回

生成物 1

HCID 60164096HCID 60164096、化合物収率 6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

7-Aminomethyl-quinolin-8-amine (Intermediate 211) (50 mg, 0.29 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (157 mg, 0.43 mmol) in MeCN (5 ml) was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo. The crude residue was purified by preparative HPLC (basic conditions) to give the title compound (4.5 mg, 6%).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude residue was purified by preparative HPLC (basic conditions)

出典と根拠

ORDレコード
ord-a81072e81dc74f008a55d7fc33eee212
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

反応ノート

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