Sulfuric Acid → 5-Bromo-8-nitroquinoline
反応式
[N+:1]([O-:4])([O-])=[O:2].[K+].[Br:6][C:7]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:8]=1[CH:9]=[CH:10][CH:11]=[N:12]2.OS(O)(=O)=O>>[Br:6][C:7]1[CH:16]=[CH:15][C:14]([N+:1]([O-:4])=[O:2])=[C:13]2[C:8]=1[CH:9]=[CH:10][CH:11]=[N:12]2参加物
4
実験手順
KNO3 (1.58 g, 15.6 mmol) was added portionwise to a solution of 5-bromoquinoline (2.0 g, 12.0 mmol) conc.H2SO4 (7.5 ml) at 0° C. and the mixture was stirred at room temperature for 16 h. The mixture was poured onto ice and the resulting solid was extracted into DCM. The organic phase was washed with brine, dried (Na2SO4) and concentrated in vacuo to give the title compound (2.8 g, 92%) which was used in the next step without further purification.
後処理
- additionThe mixture was poured onto ice
- extractionthe resulting solid was extracted into DCM
- washThe organic phase was washed with brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-aa03e42816884cf8abb18e9940d8fa0b
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102688B2
反応ノート
読み込み中…