4-Chloro-8-nitroquinazoline → HCID 11462514、化合物

HRID 513743

反応式

HRID 513743 の反応式
O.[C:2]1([CH3:13])[CH:7]=[CH:6][C:5]([S:8]([NH:11][NH2:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl[C:15]1[C:24]2[C:19](=[C:20]([N+:25]([O-:27])=[O:26])[CH:21]=[CH:22][CH:23]=2)[N:18]=[CH:17][N:16]=1>C(Cl)Cl>[CH3:13][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][NH:12][C:15]2[C:24]3[C:19](=[C:20]([N+:25]([O-:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 114584714-Chloro-8-nitroquinazolineHCID 86669768HCID 86669768、化合物

生成物 1

HCID 11462514HCID 11462514、化合物収率 95%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

p-Toluene sulphonyl hydrazine hydrate (390 mg, 2.1 mmol) was added to a solution of 4-chloro-8-nitro-quinazoline 477 (400 mg, 1.91 mmol) in DCM at (10 ml) and the mixture was stirred at room temperature for 24 h. The mixture was concentrated in vacuo and washed with Et20 to give the title compound (650 mg, 95%).

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. washwashed with Et20

出典と根拠

ORDレコード
ord-df26422ddfb343fabb844c4eb5bb9369
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

関連ノート

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