m-Chloroperbenzoic acid → 1-Oxo-1lambda~5~-1,5-naphthyridine

HRID 513748ノート

反応式

HRID 513748 の反応式
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[N:12]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1>C(Cl)Cl>[N+:12]1([O-:9])[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 1360701,5-Naphthyridine

生成物 1

HCID 3392321-Oxo-1lambda~5~-1,5-naphthyridine収率 84.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

m-CPBA (1.2 g, 6.91 mmol) was added in 3 portions (after every 3 h) to a solution of 1,5-naphthyridine (1.0 g, 7.68 mmol) in dry DCM (60 ml). After completion of the reaction, the mixture was concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent to get title compound (0.85 g, 76%).

後処理

  1. customAfter completion of the reaction
  2. concentrationthe mixture was concentrated in vacuo
  3. customThe crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent

出典と根拠

ORDレコード
ord-961c72abf7164039bb788d5de36401b8
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

反応ノート

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