1-Phenyl-2-propanol → Phenylacetone

HRID 514371

反応式

HRID 514371 の反応式
[C:1]1([CH2:7][CH:8]([OH:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[C:1]1([CH2:7][C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 941851-Phenyl-2-propanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 7678Phenylacetone収率 85.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1-phenylpropan-2-ol (2.72 g, 20 mmol) in CH2Cl2 (20 mL) was added pyridinium chlorochromate (PCC, 5.4 g, 25 mmol) at 0° C. and the mixture was stirred for 3 h. The mixture was concentrated and purified by flash column chromatography (PE/EtOAc=20:1) to give the title compound (2.3 g, 84%) as a yellow oil.

後処理

  1. concentrationThe mixture was concentrated
  2. custompurified by flash column chromatography (PE/EtOAc=20:1)

出典と根拠

ORDレコード
ord-1d69b9b3861e4ae3bdfff58d082611de
出典データセット
uspto-grants-2015_08
特許番号
US09107916B2

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