Methanol → 1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene
反応式
C(=O)([O-])OCC[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([F:14])=[CH:7][C:6]=1[Cl:15].[C:18](=O)([O-])[O-:19].[Cs+].[Cs+].IC.CO>CN(C)C=O.O>[Cl:15][C:6]1[CH:7]=[C:8]([F:14])[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=1[O:19][CH3:18]参加物
7
実験手順
A solution of 15.0 g of (2-chloro-4-fluoro-5-nitrophenyl)-ethyl carbonate in 100 ml of dimethyl formamide was treated with 18.6 g of cesium carbonate, 7.1 ml of iodomethane and 7 ml of methanol and stirred overnight at room temperature. The reaction mixture was poured into water and extracted twice with ether. The extracts were washed twice with water and then with brine, dried over magnesium sulfate and concentrated to afford 11.4 g of the subtitle compound. mp. 69-70° C. Ex. 57, C.
後処理
- extractionextracted twice with ether
- washThe extracts were washed twice with water
- dry with materialwith brine, dried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-faa14b06cf2b4e0d9eae0409f8197195
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713645B1
反応ノート
読み込み中…