1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene → 2-Fluoro-5-methoxyaniline
反応式
Cl[C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[O:12][CH3:13]>C(O)C.C(N(CC)CC)C.[Pd]>[F:8][C:6]1[CH:7]=[CH:2][C:3]([O:12][CH3:13])=[CH:4][C:5]=1[NH2:9]参加物
5
実験手順
A solution of 5.63 g of 2-chloro-4-fluoro-5-nitroanisole in 90 ml of ethanol and 5 ml of triethylamine was hydrogenated at room temperature under 60 pounds per square inch with 1.0 g of 5% palladium on carbon for four hours. The catalyst was filtered off and the solvent was evaporated. The residue was slurried in chloroform and filtered thourough a plug of silica gel and then evaporated.
後処理
- filtrationThe catalyst was filtered off
- customthe solvent was evaporated
- filtrationfiltered thourough a plug of silica gel
- customevaporated
出典と根拠
- ORDレコード
- ord-a23beb2c7e7741388a604740257e9a6b
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713645B1
反応ノート
読み込み中…