Benzyl Bromide → HCID 58083510、化合物

HRID 514454

反応式

HRID 514454 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:17][OH:18])=[C:14]([OH:16])[CH:15]=1.[OH-].[Na+]>C(O)C>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:17][OH:18])=[C:14]([O:16][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:15]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 14798Sodium HydroxideHCID 3271485-Chloro-2-(hydroxymethyl)phenol

生成物 1

HCID 58083510HCID 58083510、化合物収率 28%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(Bromomethyl)benzene (323 mg, 1.89 mmol) was added to a mixture of 5-chloro-2-(hydroxymethyl)phenol (300 mg, 1.89 mmol, PREPARATION 7) and NaOH (1.1 mL, 2M in water) in ethanol (5 mL) at r.t. slowly. The reaction mixture was stirred overnight. Poured into ice water, and extracted with ethyl acetate twice, and washed the organic phase with water twice, brine and dried with anhydrous Na2SO4. The solvents were removed and the residue purified by silica gel chromatograph to give 120 mg of the title compound (28%).

後処理

  1. extractionextracted with ethyl acetate twice
  2. washwashed the organic phase with water twice
  3. dry with materialbrine and dried with anhydrous Na2SO4
  4. customThe solvents were removed
  5. customthe residue purified by silica gel chromatograph

出典と根拠

ORDレコード
ord-bd2a2b399d87489caf3a31043675f9b3
出典データセット
uspto-grants-2015_08
特許番号
US09107916B2

関連ノート

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