Cyclohexanone → 1-Cyclohexylpyrrolidine

HRID 514644ノート

反応式

HRID 514644 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]1(=O)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[O-]S([O-])(=O)=O.[Mg+2]>C1CCCCC1>[CH:6]1([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

参加物

5

反応物 3

HCID 7967Cyclohexanone2 回HCID 24083Sulfuric acid magnesium salt (1:1)HCID 31268Pyrrolidine

生成物 1

HCID 1390641-Cyclohexylpyrrolidine収率 91%

試薬・触媒・溶媒 1

HCID 8078Cyclohexane溶媒

実験手順

Cyclohexylpyrrolidine was prepared as described in the procedure below illustrated in Scheme 1. In a 3-neck reaction flask equipped with a mechanical stirrer and heating mantle, a 2 molar equivalent of pyrrolidine were mixed with 1 molar equivalent of cyclohexanone in dry cyclohexane to make a 1M solution with respect to the cyclohexanone. To the mixture, 2 molar equivalents of anhydrous MgSO4 (as dehydrating agent) were added. The resulting mixture was refluxed for 94 hours. The progress of the reaction was monitored by NMR analysis.

後処理

  1. customIn a 3-neck reaction flask equipped with a mechanical stirrer
  2. temperatureheating mantle
  3. temperatureThe resulting mixture was refluxed for 94 hours

出典と根拠

ORDレコード
ord-b7724158c78141338e8d3ee33dce76d4
出典データセット
uspto-grants-2015_08
特許番号
US09108856B2

反応ノート

読み込み中…