Methylamine → 6-Chloro-N-methyl-1,3-benzothiazol-2-amine

HRID 514835ノート

反応式

HRID 514835 の反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][NH2:13]>C1COCC1.O>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:13][CH3:12])[S:3][C:4]=2[CH:10]=1

参加物

5

反応物 2

HCID 6329MethylamineHCID 771762,6-Dichlorobenzothiazole

生成物 1

HCID 107743586-Chloro-N-methyl-1,3-benzothiazol-2-amine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2,6-dichlorobenzo[d]thiazole (2 g, 10 mmol) in 10 mL THF was added 25% MeNH2 in water (3 mL) dropwise. After the addition complete, the reaction mixture was stirred at room temperature overnight. Filter off the product and washed with methanol. Drying in vacuo to yield 1.5 g of the desired compound. LC-MS: m/z 204.2 (M+H)+

後処理

  1. filtrationFilter off the product
  2. washwashed with methanol
  3. customDrying in vacuo

出典と根拠

ORDレコード
ord-0318590f01e946df9d95384d65449ffa
出典データセット
uspto-grants-2015_08
特許番号
US09108921B2

反応ノート

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