Thionyl Chloride → HCID 90315066、化合物

反応式

[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:20])=O>>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:20])=[O:5]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 469413502-Fluoro-4-(perfluoroethyl)benzoic acid

生成物 1

HCID 90315066HCID 90315066、化合物収率 93.4%

反応条件

温度: 60 °C

実験手順

To 2-fluoro-4-(1,1,2,2,2-pentafluoroethyl)benzoic acid (1 g, 3.87 mmol) was added thionyl chloride (3.67 mL, 50.36 mmol) and the reaction was stirred at 60° C. for 22 hours. Excess thionyl chloride was removed in vacuo to yield 2-fluoro-4-(1,1,2,2,2-pentafluoroethyl)benzoyl chloride (1 g, 93%) a s a viscous yellow liquid.

後処理

customExcess thionyl chloride was removed in vacuo

出典と根拠

ORDレコード: ord-0879880738ce41e3b7c6712175e19b78
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09108903B2

反応ノート

読み込み中…

参加物