Trifluoroacetic acid → 2-Fluoro-4-(piperidin-4-ylmethyl)aniline

HRID 515290ノート

反応式

HRID 515290 の反応式
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[F:22].FC(F)(F)C(O)=O>ClCCl>[F:22][C:3]1[CH:4]=[C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH:20]=[CH:21][C:2]=1[NH2:1]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67193052Tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate

生成物 1

HCID 671959362-Fluoro-4-(piperidin-4-ylmethyl)aniline収率 118.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate (6.49 mmol, 2 g) was dissolved in dichloromethane (5 mL). Trifluoroacetic acid (3 mL) was added and the reaction mixture stirred at room temperature for 30 minutes. The reaction mixture was purified by SCX chromatography to give the intermediate 2-fluoro-4-(piperidin-4-ylmethyl)aniline (1.6 g) as a colourless oil.

後処理

  1. customThe reaction mixture was purified by SCX chromatography

出典と根拠

ORDレコード
ord-76db2c94a0b54794bb75234748a516d8
出典データセット
uspto-grants-2015_08
特許番号
US09108939B2

反応ノート

読み込み中…