Trifluoroacetic acid → HCID 61684683、化合物

HRID 515317ノート

反応式

HRID 515317 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH:12]1[CH2:11][CH2:10][CH:9]([S:8][C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][CH:4]=2)[CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 18538812Tert-butyl 4-(4-aminophenylthio)piperidine-1-carboxylate

生成物 1

HCID 61684683HCID 61684683、化合物収率 72%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-Butyl 4-(4-aminophenylthio)piperidine-1-carboxylate (9.27 mmol, 2.859 g) was dissolved in dichloromethane (10 ml) and trifluoroacetic acid (10 mL) and the reaction mixture stirred at room temperature for 30 minutes. The reaction mixture was purified via SCX column chromatography to afford the title compound (1.39 g).

後処理

  1. customThe reaction mixture was purified via SCX column chromatography

出典と根拠

ORDレコード
ord-e56cebc3698644ac9c0709153577fa9b
出典データセット
uspto-grants-2015_08
特許番号
US09108939B2

反応ノート

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