Sodium Hydroxide → 4-(3-(Cyclopropylmethyl)ureido)benzoic acid

HRID 515325ノート

反応式

HRID 515325 の反応式
[CH:1]1([CH2:4][NH:5][C:6](=[O:19])[NH:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH2:4][NH:5][C:6](=[O:19])[NH:7][C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:17][CH:18]=2)[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

生成物 1

HCID 580558194-(3-(Cyclopropylmethyl)ureido)benzoic acid収率 93.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate (55.3 mmol, 14.5 g) was suspended in ethanol (400 mL) and 4M sodium hydroxide (332 mmol, 83 mL) added. The reaction was then refluxed until complete saponification was achieved. The ethanol was removed by evaporation and the reaction neutralised with concentrated hydrochloric acid. The white precipitate was collected and washed with water. The material was dried under vacuum to give the title compound (12.1 g).

後処理

  1. temperatureThe reaction was then refluxed until complete saponification
  2. customThe ethanol was removed by evaporation
  3. customthe reaction neutralised with concentrated hydrochloric acid
  4. customThe white precipitate was collected
  5. washwashed with water
  6. customThe material was dried under vacuum

出典と根拠

ORDレコード
ord-c504d9ca6e2f4b2bb229cc65251b51d4
出典データセット
uspto-grants-2015_08
特許番号
US09108939B2

反応ノート

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