Acetonitrile → 1350343-61-1

HRID 515401ノート

反応式

HRID 515401 の反応式
Cl.[Cl:2][C:3]1[C:8]2[S:9][C:10]([C:12]([NH:14][C@@H:15]3[CH:20]4[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]4)[CH2:16]3)=[O:13])=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.C(#N)C>O>[OH2:13].[ClH:2].[Cl:2][C:3]1[C:8]2[S:9][C:10]([C:12]([NH:14][C@@H:15]3[CH:20]4[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]4)[CH2:16]3)=[O:13])=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 6342Acetonitrile2 回HCID 46208542Encenicline Hydrochloride2 回

生成物 1

HCID 545971881350343-61-1

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

The present invention further includes a method for preparing the crystalline Form II, the method comprising: (a) adding (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride to (i) acetonitrile or (ii) aqueous acetonitrile to create a composition that is 10-20% by weight of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride; (b) optionally adding water to the composition to make the water content 6-10%; (c) optionally cooling the solution at below 10° C.; (d) allowing crystals to form; and (e) isolating crystalline (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate.

後処理

  1. customto form

出典と根拠

ORDレコード
ord-2d47ea98d65b4f42ab40aedf32b608b6
出典データセット
uspto-grants-2015_08
特許番号
US09108961B2

反応ノート

読み込み中…