3-methyl-N-(1-methylethyl)-2-nitrobenzamide → 2-amino-3-methyl-N-(1-methylethyl)benzamide

HRID 516499ノート

反応式

HRID 516499 の反応式
[CH3:1][C:2]1[C:3]([N+:14]([O-])=O)=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6].[H][H]>C(O)C.[Pd]>[NH2:14][C:3]1[C:2]([CH3:1])=[CH:13][CH:12]=[CH:11][C:4]=1[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6]

参加物

5

反応物 2

HCID 8902723-methyl-N-(1-methylethyl)-2-nitrobenzamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 167760932-amino-3-methyl-N-(1-methylethyl)benzamide収率 96.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The 2-nitrobenzamide of Step A (1.70 g, 7.6 mmol) was hydrogenated over 5% Pd/C in 40 mL of ethanol at 50 psi. When the uptake of hydrogen ceased the reaction was filtered through Celite® diatomaceous filter aid and the Celite® was washed with ether. The filtrate was evaporated under reduced pressure to afford 1.41 g of the title compound as a solid melting at 149-151° C.

後処理

  1. filtrationwas filtered through Celite® diatomaceous filter aid
  2. washthe Celite® was washed with ether
  3. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-5aeaad0e7e8942e2a98a4bff28aa9c59
出典データセット
uspto-grants-2015_08
特許番号
US09113630B2

反応ノート

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