3-Amino-6-chloro-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamide → 3-Amino-N-ethyl-2-hydroxy-N-methoxybenzenesulfonamide

HRID 516922ノート

反応式

HRID 516922 の反応式
[NH2:1][C:2]1[C:3]([OH:17])=[C:4]([S:9]([N:12]([O:15][CH3:16])[CH2:13][CH3:14])(=[O:11])=[O:10])[C:5](Cl)=[CH:6][CH:7]=1>CCO.[Pd]>[NH2:1][C:2]1[C:3]([OH:17])=[C:4]([S:9]([N:12]([CH2:13][CH3:14])[O:15][CH3:16])(=[O:10])=[O:11])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 866386363-Amino-6-chloro-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamide

生成物 1

HCID 866386403-Amino-N-ethyl-2-hydroxy-N-methoxybenzenesulfonamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A dispersion of 10% Pd/C (200 mg) in a solution of 3-amino-6-chloro-2-hydroxy-N-methoxy-N-ethyl-benzenesulfonamide (Int. FA step 2) (400 mg, 1.425 mmol) in EtOH (50 ml) was placed under a positive pressure of hyrdrogen at 0.5 bar above atmospheric pressure. After 5 hours, the catalyst was removed by filtration through Celite® (filter material), and the filtrate was reduced in vacuo. The resulting solid was used in the next step, without further purification.

後処理

  1. customthe catalyst was removed by filtration through Celite® (filter material)
  2. customThe resulting solid was used in the next step, without further purification

出典と根拠

ORDレコード
ord-4d430165cc83427dae17bb0512604483
出典データセット
uspto-grants-2015_08
特許番号
US09115087B2

反応ノート

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